When should you prefer struct layouts and VarHandle and when should you avoid it?

In Java, struct layouts and VarHandle should be preferred in scenarios where performance and direct memory access are critical. This is particularly relevant for systems programming, low-latency applications, or when interfacing with native code where precise control over data structures is necessary. However, it should be avoided when portability, ease of use, and maintainability are more important, as these approaches can lead to complex code and platform-specific behavior.